发明名称 |
ANTIBODIES TO OXIDIZED LDL |
摘要 |
A method is described for obtaining antibodies binding specifically to an epitope resulting from in vivo modification of a biomolecule or biomolecular complex, where the in vivo modification results from expression of a transgene in an animal. An example of such a biomolecule or biomolecular complex is LDL and an example of such a transgene is human myeloperoxidase. Resulting antibodies and methods of using the antibodies are also described. |
申请公布号 |
US2014154705(A1) |
申请公布日期 |
2014.06.05 |
申请号 |
US201213587914 |
申请日期 |
2012.08.16 |
申请人 |
Manneh Victor |
发明人 |
Manneh Victor |
分类号 |
G01N33/92;C07K16/18 |
主分类号 |
G01N33/92 |
代理机构 |
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代理人 |
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主权项 |
1. A method for producing antibodies specific for in vivo-modified biomolecules, comprising
screening monoclonal antibody clones for specific binding activity to an in vivo modification epitope on a biomolecule or biomolecular complex, wherein said antibody clones are derived from a transgenic animal expressing a transgene, wherein expression of said transgene results in said in vivo modification or an increase in the level of said in vivo modification; and identifying antibody clones having said specific binding activity.
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地址 |
San Diego CA US |