发明名称 |
Method for synthesis of (1S, 2R)-milnacipran |
摘要 |
The present invention relates to a method for synthesizing a pharmaceutically acceptable acid addition salt of (1S, 2R)-milnacipran comprising the following successive steps: (a) reaction of phenylacetonitrile and of (R)-epichlorhydrin in the presence of a base containing an alkaline metal, followed by a basic treatment, and then by an acid treatment in order to obtain a lactone; (b) reaction of said lactone with MNEt |
申请公布号 |
AU2010209686(B2) |
申请公布日期 |
2014.06.05 |
申请号 |
AU20100209686 |
申请日期 |
2010.01.29 |
申请人 |
PIERRE FABRE MEDICAMENT |
发明人 |
NICOLAS, MARC;HELLIER, PAUL;DIARD, CATHERINE;SUBRA, LAURENT |
分类号 |
C07C231/18;C07C233/58;C07C237/20 |
主分类号 |
C07C231/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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