Human Monoclonal Antibodies to Activin Receptor-like Kinase-1

摘要

-111 Abstract The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that bind to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and that function to abrogate the ALK-1/ TGF-beta-1 /Smad1 signaling pathway. The invention also relates to 5 heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-ALK-1 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention. ~-cc JI,: CN) ><<: C(-' a aa-a ~ c/J CN