METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A NOVEL MTOR COMPLEX

摘要

Provided herein is a novel mTOR-comprising complex, mT-ORC3, which comprises mTOR and the Ets transcription factor TEL2. Specific mTORC3 binding agents and modulating agents are provided, along with kits and methods for the detection of mTORC3. Methods of modulating the activity of mTORC3 or modulating cell growth and/or survival are also provided. Further provided are methods for screening for mTORC3 binding agents and for mTORC3 modulating agents. Various methods of diagnosis and treatment are further provided.

主权项

1. An isolated mTOR complex 3 (mTORC3), wherein said mTORC3 comprises:
a) a first polypeptide comprising an mTOR polypeptide or a biologically active variant or fragment thereof; and b) a second polypeptide comprising a TEL2 polypeptide or a biologically active variant or fragment thereof.