发明名称 PIPERAZINE DERIVATIVES, METHODS FOR PREPARING SAME, AND USES THEREOF IN THE TREATMENT OF INSULIN RESISTANCE
摘要 The invention relates to a compound of formula (I), where R1, R2, R3, m, n, and L1 are as defined in claim 1, to the methods for preparing same, to the pharmaceutical compositions containing same, and to the uses thereof in the treatment of diseases associated with insulin resistance syndrome.;
申请公布号 US2014155409(A1) 申请公布日期 2014.06.05
申请号 US201214128381 申请日期 2012.06.22
申请人 Moinet Gerard;Baverel Gabriel;Nazaret Remi;Ferrier Bernard 发明人 Moinet Gerard;Baverel Gabriel;Nazaret Remi;Ferrier Bernard
分类号 C07D241/20;C07D295/088;A61K31/497;C07D213/74;A61K31/496;A61K45/06;A61K31/495 主分类号 C07D241/20
代理机构 代理人
主权项 1. Compound of formula (I)in which: R1 represent a —(CH2)4C(O)OH group; n represents 0 or 1; m represents an integer ranging from 0 to 8; L1 represents a —C(O)—; —C(O)O— or —S(O)2— group; R2 represents: a carbocycle group with 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a polycarbocycle group with 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a heterocycle group with 5, 6 or 7 members, substituted or non-substituted, saturated, partially unsaturated or aromatic, comprising 1, 2 or 3 heteroatoms, identical or different;a polyheterocycle group with 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic, comprising 1, 2 or 3 heteroatoms identical or different;a -L2-carbocycle group, the carbocycle being in 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a -L2-polycarbocycle, the polycarbocycle being in 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a -L2-heterocycle group, the heterocycle being in 5, 6 or 7 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different;a -L2-polyheterocycle group, the polyheterocycle being in 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 hetero atoms, identical or different; ora hydrocarbon group, linear or branched, C1 to C5; L2 represents an alkyl, linear or branched, C1 to C5; R3, identical or different, represent: an alkyl, linear or branched, C1 to C5;a -L2-carbocycle group, the carbocycle being in 5, 6 or 7 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a -L2-polycarbocycle, the polycarbocycle being in 8 to 14 members, saturated, partially unsaturated or aromatic, substituted or non-substituted;a -L2-heterocycle group, the heterocycle being in 5, 6 or 7 members, substituted or non- substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different, in particular chosen from nitrogen, oxygen or sulphur; ora -L2-polyheterocycle group, the polyheterocycle being in 8 to 14 members, substituted or non-substituted, saturated, partially unsaturated or aromatic and comprising 1, 2 or 3 heteroatoms, identical or different, in particular chosen from nitrogen, oxygen or sulphur; isomers, enantiomers and diastereoisomers thereof and the addition salts thereof with pharmaceutically acceptable bases or acids.
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