QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

摘要

The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (I) below.;;These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.

主权项

1. A compound represented by formula I:or a pharmaceutically acceptable salt, wherein
X is O, S, CH2, or —CONH—; B is a C3 to C9 alkylene; R1 is selected from hydrogen, C1 to C4 alkoxy or substituted C1 to C4 alkoxy; R2 is each independently selected from halogen, C1 to C4 alkyl, C2 to C4 alkenyl, and C2 to C4 alkynyl; and n is 1, 2 or 3.