发明名称 |
METHOD OF TARGETING SPECIFIC CELL POPULATIONS USING CELL-BINDING AGENT MAYTANSINOID CONJUGATES LINKED VIA A NON-CLEAVABLE LINKER, SAID CONJUGATES AND METHODS OF MAKING SAID CONJUGATES |
摘要 |
The present invention discloses a method for targeting maytansinoids to a selected cell population, the method comprising contacting a cell population or tissue suspected of containing the selected cell population with a cell-binding agent maytansinoid conjugate, wherein one or more maytansinoids is covalently linked to the cell-binding agent via a non-cleavable linker and the cell-binding agent binds to cells of the selected cell population. |
申请公布号 |
US2014154804(A1) |
申请公布日期 |
2014.06.05 |
申请号 |
US201414172360 |
申请日期 |
2014.02.04 |
申请人 |
IMMUNOGEN INC. |
发明人 |
CHARI Ravi V.J.;BLATTLER Walter A. |
分类号 |
C07K16/18 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Waltham MA US |