| 发明名称 |
ARTERIVIRUS |
| 摘要 |
The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes. |
| 申请公布号 |
US2014154265(A1) |
申请公布日期 |
2014.06.05 |
| 申请号 |
US201314035415 |
申请日期 |
2013.09.24 |
| 申请人 |
Kikkert Marjolein;Mark Brian Leonard;van Kasteren Puck Bertyne;James Terrence William;Snijder Eric John |
发明人 |
Kikkert Marjolein;Mark Brian Leonard;van Kasteren Puck Bertyne;James Terrence William;Snijder Eric John |
| 分类号 |
A61K39/12;A61K39/40;A61K39/02;A61K39/42 |
主分类号 |
A61K39/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A replication-competent Arterivirus, characterized in that said virus has a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2.
|
| 地址 |
Sassenheim NL |
