Biological Markers and Methods for Predicting Response to B-Cell Antagonists

摘要

Biological markers that predict patient responsiveness to B-cell antagonists are provided. Also provided are methods of using such biological markers. In addition, methods for identifying patients suffering from an autoimmune disease, e.g., rheumatoid arthritis, who are not likely to respond to B-cell antagonists are provided, as are methods of treating such patients. Methods for selecting therapeutic agents to treat such patients are also provided.

主权项

1. A biomarker for predicting the response of a patient to a therapeutic agent comprising a B-cell antagonist, wherein the biomarker comprises elevated total plasma/plasmablast cell mRNA in a biological sample obtained from the patient compared to the level of total plasma/plasmablast cell mRNA in a biological sample obtained from a control subject or compared to a threshold value for total plasma/plasmablast cell mRNA.