Method for catalytic manufacture of aromatic or heteroaromatic nitriles

摘要

Preparation of optionally substituted aromatic or heteroaromatic nitriles (I) by conversion of corresponding halides (or sulfonates) (II) is carried out in presence of (A) copper compounds and (B) monodentate, 5- or 6-membered heteroaromatic amines containing 1-3 nitrogen atoms, using (C) potassium hexacyanoferrate (II) or potassium hexacyanoferrate (III) as cyanide donor. Catalytic preparation of nitriles of formula Ar-CN (I) by conversion of corresponding halides or sulfonates of formula Ar-X (II) is carried out in presence of (A) copper compounds and (B) monodentate, 5- or 6-membered heteroaromatic amines containing 1-3 nitrogen atoms, using (C) potassium hexacyanoferrate (II) or potassium hexacyanoferrate (III) as cyanide donor. X : Cl, Br, I or sulfonate; Ar : optionally substituted aromatic or heteroaromatic residue.