| 发明名称 |
Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| 摘要 |
<p>An isolated anti-ICOS antibody comprising a VH domain, a VK domain and a variant Fc region, wherein the antibody mediates enhanced ADCC activity as compared to the level of ADCC activity mediated by a parent antibody comprising the VH and VK domains and a wild type Fc region.</p> |
| 申请公布号 |
EP2737907(A2) |
申请公布日期 |
2014.06.04 |
| 申请号 |
EP20130182515 |
申请日期 |
2008.05.07 |
| 申请人 |
MEDIMMUNE, LLC |
发明人 |
COYLE, ANTHONY;YAO, YIHONG;JALLAL, BAHIJA;CARLESSO, GIANLUCA;BOWEN, MICHAEL |
| 分类号 |
A61K39/395;A61K39/00;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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代理人 |
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