发明名称 |
SUMOYLATION OF SERCA2A AND CARDIOVASCULAR DISEASE |
摘要 |
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation. |
申请公布号 |
EP2736516(A1) |
申请公布日期 |
2014.06.04 |
申请号 |
EP20120811596 |
申请日期 |
2012.07.13 |
申请人 |
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI |
发明人 |
HAJJAR, ROGER, JOSEPH;KHO, CHANG, WON;LEE, AH, YOUNG |
分类号 |
A61K31/7088;C12N15/11;C12N15/113 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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