发明名称 |
METHODS AND COMPOSITIONS FOR MODULATING THE INNATE IMMUNE RESPONSE AND/OR MYOGENESIS IN A MAMMALIAN SUBJECT |
摘要 |
<p>In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of DUX4-fl, or modulating the expression of beta-defensin 3 (DEFB103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (DEFB103). In additional aspects, the present invention involves diagnostic methods based on assessment of identified biomarkers.</p> |
申请公布号 |
EP2736531(A2) |
申请公布日期 |
2014.06.04 |
申请号 |
EP20120819621 |
申请日期 |
2012.07.27 |
申请人 |
FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
TAPSCOTT, STEPHEN, J.;GENG, LINDA |
分类号 |
C12Q1/68;A61K48/00;C12N15/11 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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