Method for selecting a candidate drug compound

摘要

The disclosure relates to the field of candidate drug testing and drug development. Described are methods for providing a compound composed of at least one molecule attached via at least two linkages to a molecular scaffold, the method comprising providing a scaffold comprising at least a first and a second reactive group; providing at least one molecule able to react with the at least first and second reactive group; and contacting the scaffold with at least one molecule to form at least two linkages between the scaffold and the molecule in a coupling reaction, wherein the formation of a linkage accelerates the formation of a consecutive linkage. The coupling reaction may be performed in solution, such as an aqueous solution. Furthermore, described is a method for selecting a candidate drug compound comprising providing a library of the compounds and determining the binding of a target molecule to the compounds.

主权项

1. A compound comprising at least two looped peptide structures attached via at least three thioether linkages to an aromatic or heteroaromatic molecule, wherein each of the at least three thioether linkages comprises a sulfur at a benzylic position on said aromatic or heteroaromatic molecule.