| 发明名称 |
Polypeptide vaccine and vaccination strategy against mycobacterium |
| 摘要 |
A vaccine is provided wherein a polypeptide or combination of peptides from M. tuberculosis is administered to a subject to elicit an immune response. The polypeptide vaccine is administered as part of a prime-boost strategy with BCG vaccine to increase the immunoprotection in a subject such that prevention or elimination of disease is achieved. Finally, a pharmaceutical package is provided that encompasses a polypeptide vaccine for M. tuberculosis that when administered to a subject elicits immunoprotection. |
| 申请公布号 |
US8741313(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US20090812541 |
申请日期 |
2009.01.12 |
| 申请人 |
Emory University;The United States of America, as represented by the Secretary, Department of Health and Human Services |
发明人 |
Sable Suraj;Plikaytis Bonnie B.;Shinnick Thomas M.;Amara Rama Rao;Cheruvu Manl |
| 分类号 |
A61K39/00;A61K39/02;A61K39/04;A61K39/116;A61K45/00 |
主分类号 |
A61K39/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A vaccine comprising:
a non-glycosylated M. tuberculosis polypeptide of Rv1324, or a combination of M. tuberculosis polypeptides of Ag85A, Ag85B, MPT-64, Pst-S1, Apa, GroES, GroEL, Dnak, non-glycosylated Rv1324, and CFP10; and an adjuvant.
|
| 地址 |
Atlanta GA US |
