Siglec 15 antibodies in treating bone loss-related disease

摘要

Novel antibodies and antigen binding fragments that specifically binds to Sιglec-15 are described herein. In some embodiments, the antibodies or antigen binding fragments may block the biological activity of Sιglec-15 and are useful in composition for the treatment of bone loss, more particularly in bone diseases that have increased cell surface expression of Sιglec-15, such as conditions where there is an increase in the bone degradative activity of osteoclasts. The invention also relates to cells expressing the antibodies or antigen binding fragments such as monoclonal, humanized or chimeric antibodies. Additionally, methods of detecting and treating bone loss, bone-related diseases or cancer using the antibodies and fragments are also disclosed.

主权项

1. An isolated antibody or an antigen binding fragment thereof having a light chain variable domain comprising the amino acid sequence set forth in SEQ ID NO:111, the amino acid sequence set forth in SEQ ID NO:112 and the amino acid sequence set forth in SEQ ID NO:113 and a heavy chain variable domain comprising the amino acid sequence set forth in SEQ ID NO:114, the amino acid sequence set forth in SEQ ID NO:115 and the amino acid sequence set forth in SEQ ID NO:116, wherein said antibody or antigen binding fragment specifically binds Siglec-15.