| 发明名称 |
Anti-infective agents against intracellular pathogens |
| 摘要 |
A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of Formula I:;
wherein X wherein X is —CF3, Ar is selected from
;
and R is selected from
;whereR′ is L-Lys, D-Lys, β-Ala, L-Lue, L-Ile, Phe, SO2CH2CH2NH2, SO2NH2, Asn, Glu or Gyl, andR″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2,; |
| 申请公布号 |
US8741944(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US201313869386 |
申请日期 |
2013.04.24 |
| 申请人 |
The Ohio State University Research Foundation |
发明人 |
Chen Ching-Shih;Chiu Hao-Chieh;Wang Dasheng |
| 分类号 |
C07D231/12;C07D403/10;A61K31/5415 |
主分类号 |
C07D231/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of Formula I wherein X is —CF3, Ar is and R is selected from R′ is SO2CH2CH2NH2 or SO2NH2 or an amino acid attached through a peptide bond including the α-carboxyl group of an amino acid selected from the group consisting of L-Lys, D-Lys, β-Ala, L-Leu, L-Ile, Phe, Asn, Glu and Gly, and R″ is methyl, ethyl, allyl, CH2CH2OH, CH2CN, CH2CH2CN, CH2CONH2, or pharmaceutically acceptable salts thereof.
|
| 地址 |
Columbus OH US |
