| 发明名称 |
Monoclonal antibodies against ANGPTL3 |
| 摘要 |
Monoclonal antibodies that specifically bind to ANGPTL3 are provided. Monoclonal antibodies that neutralize at least one activity of ANGPTL3 are provided. Methods of treating a disorder of lipid metabolism using neutralizing monoclonal antibodies are provided. |
| 申请公布号 |
US8742075(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US201113073617 |
申请日期 |
2011.03.28 |
| 申请人 |
Lexicon Pharmaceuticals, Inc. |
发明人 |
Lee E-Chiang;Landes Gregory;Hong Seokjoo;Desai Urvi;Powell David;Feng Xiao |
| 分类号 |
C07K16/26;C07K16/00;A61K39/395 |
主分类号 |
C07K16/26 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A monoclonal antibody that binds to angiopoietin-like protein 3 (ANGPTL3) and neutralizes at least one activity of ANGPTL3, wherein the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO: 9 with at least 3-fold greater affinity than the antibody binds to a peptide consisting of the amino acid sequence of SEQ ID NO: 86, 87, or 88.
|
| 地址 |
The Woodlands TX US |
