Saccharide-containing protein conjugates and uses thereof

摘要

Conjugates of a saccharide and a biomolecule, covalently linked therebetween via a non-hydrophobic linker and methods of preparing same are disclosed. Also disclosed are medical uses utilizing such conjugates. Glycosylation reagents for use in preparing these conjugates are also disclosed. Glycosylated proteins, characterized by improved performance, are also disclosed.

主权项

1. A conjugate comprising a single lysosomal protein and a saccharide moiety being covalently linked to said lysosomal protein via a non-hydrophobic linker, said linker being a non-saccharide linker and comprising a poly(alkylene glycol) of at least 18 atoms in length, and said saccharide moiety being a M6P.