Composite extracellular matrix materials and medical products formed therefrom

摘要

Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non-expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.

主权项

1. A composite extracellular matrix material product, comprising:
a dried compressed foam body that expands when wetted, said dried compressed body formed by compression of a cast body having introduced chemical crosslinks, said cast body including a first extracellular matrix material that has been treated with an alkaline medium under conditions effective to produce an expanded extracellular matrix material having a tensile strength of less than 50% of the tensile strength of an original tensile strength of the extracellular matrix material and particles of a second extracellular matrix material entrapped within said cast body, wherein said particles increase a rate of expansion of said dried compressed body when wetted, and further wherein said introduced chemical crosslinks are sufficient to increase the resiliency of the foam body.