| 发明名称 |
Immunoconjugates with an intracellularly-cleavable linkage |
| 摘要 |
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates. |
| 申请公布号 |
US8741300(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US201113291238 |
申请日期 |
2011.11.08 |
| 申请人 |
Immunomedics, Inc. |
发明人 |
Govindan Serengulam V.;Moon Sung-Ju;Goldenberg David M. |
| 分类号 |
A61P37/06;C07K16/00;C07K14/00 |
主分类号 |
A61P37/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating autoimmune disease, comprising administering to a subject with an autoimmune disease a conjugate having a structural formula of MAb-CL2A-SN-38, with a structure represented by:wherein said MAb is selected from the group consisting of hLL1, hLL2, RFB4, hA19, hA20 and hL243.
|
| 地址 |
Morris Plains NJ US |
