| 发明名称 |
Naturally occurring autoantibodies against alpha-synuclein that inhibit the aggregation and cytotoxicity of alpha-synuclein |
| 摘要 |
The present invention refers to human antibodies which are directed against α-Synuclein (α-Syn) and their use in medicine and diagnosis. |
| 申请公布号 |
US8741293(B2) |
申请公布日期 |
2014.06.03 |
| 申请号 |
US201113582489 |
申请日期 |
2011.03.03 |
| 申请人 |
Dr. Rentschler Holding GmbH & Co. KG |
发明人 |
Dodel Richard;Bacher Michael;Besong Agbo Daniela;Hagemann Sascha;Balzer-Geldsetzer Monika;Rehberger Bernd;Weber Renee |
| 分类号 |
C07K16/18;A61K39/395;A61K39/00;C12P21/00 |
主分类号 |
C07K16/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated human antibody which is directed against an epitope between amino acids 60-100 of human α Synuclein (α-Syn), or a fragment of said antibody, which comprises a heavy chain comprising complementarity determining regions CDR1, CDR2, and CDR3, wherein CDR1 is selected from the sequences shown in SEQ ID NOs.: 76-80, CDR2 is selected from the sequences shown in SEQ ID NOs.: 82-85, and CDR3 is selected from the sequences shown in SEQ ID NOs.: 86-91.
|
| 地址 |
Laupheim DE |
