发明名称 |
ANTIBACTERIAL QUINOLINE DERIVATIVES |
摘要 |
The present invention relates to novel substituted quinoline derivatives according to the general Formula (Ia) or Formula (Ib): the pharmaceutically acceptable acid or base addition salts thereof, the quaternary amines thereof, the stereochemically isomeric forms thereof, the tautomeric forms thereof and the N-oxide forms thereof. The claimed compounds are useful for the treatment of a bacterial disease including a mycobacterial disease, particularly those diseases caused by pathogenic mycobacteria such as Mycobacterium tuberculosis, M. bovis, M. avium and M. marinum. Also claimed is a composition comprising a pharmaceutically acceptable carrier and, as active ingredient, a therapeutically effective amount of the claimed compounds, the use of the claimed compounds or compositions for the manufacture of a medicament for the treatment of bacterial diseases and a process for preparing the claimed compounds. |
申请公布号 |
CA2614981(C) |
申请公布日期 |
2014.06.03 |
申请号 |
CA20062614981 |
申请日期 |
2006.07.26 |
申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
GUILLEMONT, JEROME EMILE GEORGES;LANCOIS, DAVID FRANCIS ALAIN;PASQUIER, ELISABETH THERESE JEANNE;ANDRIES, KOENRAAD JOZEF LODEWIJK MARCEL;KOUL, ANIL |
分类号 |
C07D215/227;A61K31/47;A61P31/00;C07D215/12;C07D215/48;C07D401/04;C07D401/06;C07D401/12;C07D401/14;C07D405/06;C07D405/12;C07D413/06;C07D417/06 |
主分类号 |
C07D215/227 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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