Substituted amides, manufacturing and use thereof as medicaments

摘要

The present invention relates to new substituted prolinamides of general formula (I) wherein D, Y, A, B, R3, R4 and R5 are defined as in the specification, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases, which have valuable properties.;

主权项

1. Compounds of formula (I), wherein D denotes a substituted bicyclic ring system of formula (II) wherein
K1 and K4 each independently of one another denote a —CH2, —CHR2a—or a —CR2bR2c group represent, and whereinR2a/R2b/R2c each independently of one another denote a methyl group, or two groups R2b/R2c together with the cyclic carbon atom may form a cyclopropyl ring, andK2 and K3 each independently of one another denote a —CH2, —CHR6a or —CR6bR6c—group, whereinR6a/R6b/R6c each independently of one another denote a methyl group,or two groups R6b/R6c together with the cyclic carbon atom may form a cyclopropyl ring, andR1 denotes a hydrogen atom or a C1-3-alkyl, or C3-6-cycloalkyl group, andAl denotes CR9, A2 denotes CR10, A3 denotes CR11, while R9, R10 and R11 each independently of one another denote a hydrogen, fluorine or chlorine atom, or a methyl, CF3, cyano, methoxy, CF3O, CHF2O, CH2FO—group, and Y denotes a carbonyl group, and A denotes an oxygen atom, and R3, R4 and R5 each represent a hydrogen atom, and B denotes a thiophene ring according to formula (III), which is bound to the carbonyl group in formula (I) via the 2 position and which is substituted in the 5 position by R7, where R7 denotes a chlorine or bromine atom, or an ethynyl group, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof.