发明名称 Polylactides compositions and uses thereof
摘要 The present invention provides compositions and methods relating to polylactides which may be used for drug delivery (e.g., parenteral delivery), wherein an organic solvent is not required.
申请公布号 US8741877(B2) 申请公布日期 2014.06.03
申请号 US201313778038 申请日期 2013.02.26
申请人 University of Geneva 发明人 Moller Michael;Trimaille Thomas;Gurny Robert
分类号 A01N37/18;A61K31/65 主分类号 A01N37/18
代理机构 代理人
主权项 1. A method of drug delivery, comprising administering a pharmaceutical composition comprising a drug and a polylactide to a subject, wherein the polylactide has the structure: wherein R1, R2, R3, and R4 are each independently chosen from the group consisting of unsubstituted C1-20 alkyl, H, C2-20 alkenyl, and —(CH2)y—(C6H5); wherein y=1-20; wherein n is 2 to 100; wherein X is hydrogen or —C(O)—CH═CH2; wherein at least one of R1, R2, R3, and R4 is C4-20 unsubstituted alkyl, C2-20 alkenyl, or —(CH2)y—(C6H5); wherein y=1-20; wherein Y is —OH, C1-12 alkoxy, benzyloxy, or —O—(CH2—CH2—O)p—CH3; wherein p is 1 to 700; and wherein if Y is —OH, C1-12 alkoxy, or benzyloxy, then the polylactide has a Tg value of less than 15° C.
地址 Geneva CH