Real-time radiation treatment planning system

摘要

The invention relates to a real time radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body using hollow needles. According to embodiments of the invention, the system may include a processing means processing means-configured to perform a three-dimensional imaging algorithm and a three-dimensional image segmentation algorithm, with respect to one or more specific organs within the pre-selected anatomical portion and with respect to the needles, for converting the image data obtained with an imaging means into a three-dimensional image of the anatomical portion, using at least one single or multi-objective anatomy-based genetic optimization algorithm. For pre-planning or virtual simulation purposes, the processing means is arranged to determine in real time the optimal number and position of at least one of the needles, positions of energy emitting sources within the needles, and the dwell times of the energy emitting sources at the positions. For post-planning purposes, the processing means is arranged to determine, based on three-dimensional image information, in real time the real needle positions and the dwell times of the energy emitting sources for the positions.

主权项

1. A radiation treatment planning system for use in effecting radiation therapy of a pre-selected anatomical portion of an animal body, comprising:
an imaging device configured to generate image data corresponding to the anatomical portion; a positioning device configured to position the imaging device within the pre-selected anatomical portion, wherein the positioning device includes a template; a radiation delivery device configured to deliver at least one energy emitting source through at least one of a plurality of hollow needles inserted into the anatomical portion with the guidance of the template; a processor configured to generate a radiation treatment plan for effecting the radiation therapy, wherein the processor is configured to; convert the image data into a three-dimensional image of the anatomical portion; designate multiple sampling points in the three-dimensional image; calculate a radiation dose distribution for at least one sampling point, based on at least one of an actual number and position of at least one of the plurality of hollow needles, an actual position of the at least one energy emitting source within the at least one of the plurality of hollow needles, or an actual dwell time of the at least one energy emitting source at the position; and determine, based on at least one solution to an objective function, a radiation treatment plan reflecting a radiation dose via the at least one of the plurality of hollow needles, wherein a number of operations for calculating the at least one solution is independent of the number of sampling points.