Systems and methods for laser assisted sample transfer to solution for chemical analysis

摘要

Systems and methods are described for laser ablation of an analyte from a specimen and capturing of the analyte in a dispensed solvent to form a testing solution. A solvent dispensing and extraction system can form a liquid microjunction with the specimen. The solvent dispensing and extraction system can include a surface sampling probe. The laser beam can be directed through the surface sampling probe. The surface sampling probe can also serve as an atomic force microscopy probe. The surface sampling probe can form a seal with the specimen. The testing solution including the analyte can then be analyzed using an analytical instrument or undergo further processing.

主权项

1. A system for performing analysis of at least one analyte present in a solid sample, comprising:
a laser source for emitting a laser beam toward a specimen on a specimen stage to generate ablated analyte; a solvent dispensing and extraction system, the solvent dispensing and extraction system dispensing a solvent adjacent to a surface of the sample such that at least a portion of the ablated analyte can be dissolved in the solvent, wherein the solvent dispensing and extraction system forms a liquid microjunction between the solvent dispensing and extraction system and a surface of the specimen, the laser beam being focused at sample material only within the microjunction, such that the analyte is ablated directly into liquid solvent within the liquid microjunction; the solvent dispensing and extraction system having structure for extracting the analyte-containing solvent for analysis.