Pyrazolopyrimidine derivatives

摘要

Compounds of the formula (I), in which X, R1 and R2 have the meanings indicated in claim 1, are PI3K inhibitors and can be employed, inter alia, for the treatment of autoimmune diseases, inflammation, cardiovascular diseases, neurodegenerative diseases and tumors.

主权项

1. A compound selected from the following compounds:Compound No.Name and/or structure“A65” 4-(1H-Indol-6-yl)-1-methyl-6-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine“A97” 4-(1H-Indol-4-yl)-1-methyl-6-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine“A129”4-(1H-Benzimidazol-5-yl)-1-methyl-6-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine“A161”4-(1H-Indazol-4-yl)-1-methyl-6-morpholin-4-yl-1H-pyrazolo[3,4-d]pyrimidine“A193”5-(1-Methyl-6-morpholin-4-yl-1H-pyrazolo[3,4-d]-pyrimidin-4-yl)pyridin-2-ylamine“A196”“A228”“A229”“A257”Ethyl [4-(6-aminopyridin-3-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]acetate“A258”2-[4-(6-Aminopyridin-3-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidin-1-yl-ethanone“A259”Ethyl [4-(2-aminopyrimidin-5-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]acetate“A260”2-[4-(2-Aminopyrimidin-5-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]-1-pyrrolidin-1-yl-ethanone“A261”2-[4-(2-Aminopyrimidin-5-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]-1-morpholin-4-yl-ethanone“A262”2-[4-(2-Aminopyrimidin-5-yl)-6-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl]-1-(4-methyl-piperazin-1-yl)ethanoneor a pharmaceutically usable salt, tautomer or stereoisomer thereof, including mixtures thereof in all ratios.