发明名称 |
N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYDINYL)PHENYL]ACETAMIDE MESYLATE MONOHYDRATE |
摘要 |
The present invention relates to an improved and shortened synthesis of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide and the mesylate monohydrate salt thereof by using boronic acid derivatives or borolane reagents while avoiding toxic organic tin compounds and to the mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acet-amide which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions. |
申请公布号 |
KR20140066704(A) |
申请公布日期 |
2014.06.02 |
申请号 |
KR20147004026 |
申请日期 |
2012.09.26 |
申请人 |
AICURIS GMBH & CO. KG |
发明人 |
SCHWAB WILFRIED;BIRKMANN ALEXANDER;VOEGTLI KURT;HAAG DIETER;LENDER ANDREAS;GRUNENBERG ALFONS;KEIL BIRGIT;REHSE JOACHIM |
分类号 |
C07D417/12;A61K31/4402;A61P31/22 |
主分类号 |
C07D417/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|