GLYCOPROTEIN FRACTION ISOLATED FROM WHEAT BRAN AND METHOD FOR PRODUCING THE SAME

摘要

The present invention relates to a fraction of wheat bran-derived glycoprotein and a method of producing the same and, more particularly, to a fraction of wheat bran-derived glycoprotein, which is characterized by having a molecular weight of 16 to 70 kDa and prepared by a method comprising: (a) step of removing fat in wheat bran; (b) a step of mixing the wheat bran in a buffer solution having a pH level of 7.0 to 8.0; (c) a step of obtaining a supernatant by centrifuging the mixture; (d) a step of dialyzing the supernatant with a dialysis semipermeable membrane (MWCO 6000-8000); (e) a step of adding a salt precipitating protein in the dialyzed supernatant to precipitate glycoprotein; (f) a step of dissolving the precipitate in a buffer solution having a pH level of 7.0 to 8.0 with a dialysis semipermeable membrane (MWCO 6000-8000); and (g) a step of obtaining a fraction of glycoprotein from the dialyzed and precipitated lysate. The present invention also relates to a pharmaceutical food composition containing the fraction as an active ingredient for enhancing the immune function. The fraction of glycoprotein of the present invention is more effective in promoting histiocyte vitality than Krestin (PSK), which is a medicine for enhancing immune vitality, and has no cytotoxicity, thereby being effective in producing a new functional food and a medicine for enhancing the immune function.