发明名称 |
N-[5-AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2-[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MESYLATE MONOHYDRATE HAVING A SPECIFIC PARTICLE SIZE DISTRIBUTION RANGE AND A SPECIFIC SURFACE AREA RANGE FOR USE IN PHARMACEUTICAL FORMULATIONS |
摘要 |
The present invention relates to the crystalline mesylate monohydrate salt of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide in a definite particle size distribution and a specific surface area range, which has demonstrated increased long term stability and release kinetics from pharmaceutical compositions, as well as to pharmaceutical compositions containing said N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate having the afore-mentioned particle size distribution and specific surface area range. |
申请公布号 |
KR20140066705(A) |
申请公布日期 |
2014.06.02 |
申请号 |
KR20147004027 |
申请日期 |
2012.09.26 |
申请人 |
AICURIS GMBH & CO. KG |
发明人 |
SCHWAB WILFRIED;BIRKMANN ALEXANDER;PAULUS KERSTIN;VOEGTLI KURT;HAAG DIETER;MAAS STEPHAN;RUEPP KRISTIAN |
分类号 |
C07D417/12;A61K31/4402;A61P31/22 |
主分类号 |
C07D417/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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