Methods of applying physical stimuli to cells

摘要

NZ 602651 Disclosed is a method of influencing the fate of an in vitro cultured stem or progenitor cell, the method comprising administering to the cell a mechanical signal on a periodic basis and for a time sufficient to influence the fate of the cell such that it differentiates into a cell type different from the cell type it would be expected to differentiate into in the absence of the mechanical signal, wherein the frequency of the mechanical signal is 10-100 Hz and the magnitude of the mechanical signal causes the cell to accelerate at 0.0981-39.24 m/s2.