CRYSTAL STRUCTURE OF THE SERCA CA2+ ATPASE IN A COMPLEX WITH SARCOLIPIN

摘要

The present invention provides the use of a three-dimensional structural representation of at least part of the SERCA Ca2+ ATPase/SLN complex as listed in Table (i), optionally varied by a root mean square deviation of C alpha atoms of not more than 4.95 Å, or selected coordinates thereof, in a method for selecting or designing one or more binding partners of a Ca2+ ATPase and/or SLN.