The invention relates to the synthesis of boronic ester and acid compounds. More particularly, the invention provides improved synthetic processes for the large-scale production of the peptide boronic acid proteasome inhibitor bortezomib.
申请公布号
SI2377869(T1)
申请公布日期
2014.05.30
申请号
SI20050031843T
申请日期
2005.03.24
申请人
MILLENNIUM PHARMACEUTICALS, INC.
发明人
PICKERSGILL I. FRASER;BISHOP JOHN;AMMOSCATO VINCE;MUNK STEPHEN;LO YOUNG;CHIU FANG-TING;KULKARNI VITHALANAND R.
