| 摘要 |
Disclosed herein is a compound of formula (I) wherein the variables are defined in the specification, and the use thereof in the treatment of a protein kinase mediated disease, wherein the disease is treated by inhibiting SYK, PYK2, FAK, ZAP70, PIM1, FLT3, RET, JAK2, JAK3, LRRK2, LRRK2(G2019S), ABLl(T315I), AURKB, AXL, FLT3, KIT, KIT(D816V), KIT(V559D,T670I), MKNK2, MLKl, PDGFRB, PLK3, RET, SNARK, SRPK3, TAKl, or TYK2 signaling. In one embodiment the compound is 4-(3-((dimethylamino)methyl)-4-phenyl-1H-pyrrol-1-yl)-N-(3,5-dimethylphenyl)-5-fluoropyrimidin-2-amine. |
