USE OF PKC412 IN THE REACTIVATION OF LATENT HIV-1

摘要

HIV-1 latency is a major obstacle in HIV-1 eradication. Although current highly active antiretroviral therapy (HAART) has efficiently decreased the viral load in patients, latently infected cells are permanent reservoirs and inevitably lead to viral rebound upon discontinuation of HAART. Therefore, extensive efforts are being directed toward the reactivation of latent HIV reservoirs with the hope that latently infected cells will be eliminated by the host immune system and/or virus-mediated cell lysis. We are currently working on developing strategies to reactivate the latent viral reservoir in order to eliminate them. Through high-throughput screening, an anti- cancer molecule PKC412 that is able to reactivate HIV-1 expression from a HIV-1 latently infected ACH2 cell line and latently infected CD4+ T cells has been identified.