发明名称 |
EXTRACTION AND PURIFICATION OF URUSHIOL FROM BOTANICAL SOURCES |
摘要 |
The disclosure relates to methods for preparing urushiol from plants including, for example, poison ivy or poison oak. The methods include extraction of plant material using a primary organic solvent more polar than ethanol, followed by a solvent extraction using substantially immiscible solvents having substantially different polarities, such as hexane and acetonitrile. The method can include further purification, such as by fractionation of solvent- extracted materials using a thiazole-derivatized silica gel chromatography medium. The extracts thus generated can exhibit greater purity, higher concentration, and greater stability than extracts made using previously-known methods. The extracts can be particularly suitable for use in immunotherapeutic methods, such as desensitizing individuals who normally develop allergic contact dermatitis attributable to poison ivy or poison oak. |
申请公布号 |
WO2014081988(A1) |
申请公布日期 |
2014.05.30 |
申请号 |
WO2013US71355 |
申请日期 |
2013.11.21 |
申请人 |
ROWAN UNIVERSITY;YANG, CATHERINE, F.;LI, WEIXING;ELLIOTT, RYAN;ILTCHENCKO, NIKITA |
发明人 |
YANG, CATHERINE, F.;LI, WEIXING;ELLIOTT, RYAN;ILTCHENCKO, NIKITA |
分类号 |
A61K36/22;B01D11/00 |
主分类号 |
A61K36/22 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|