PROMPT NUCLEIC ACID DELIVERY CARRIER COMPOSITION

摘要

AN OBJECT OF THE PRESENT INVENTION IS TO PROVIDE A CARRIER COMPOSITION FOR NUCLEIC ACID DELIVERY, WHICH CAN EFFICIENTLY DELIVER A NUCLEIC ACID INTO CELLS WHEN A NUCLEIC ACID SUCH AS SIRNA IS ADMINISTERED TO ANIMAL-DERIVED CELLS OR ANIMALS, AND ALSO HAS LOW TOXICITY AND HIGH SAFETY, AND A COMPOSITION FOR NUCLEIC ACID DELIVERY CONTAINING THE CARRIER COMPOSITION AND NUCLEIC ACID. A CARRIER FOR NUCLEIC ACID DELIVERY IS PREPARED BY USING (A) A DIACYLPHOSPHATIDYLCHOLINE, (B) AT LEAST ONE MEMBER SELECTED FROM THE GROUP CONSISTING OF CHOLESTEROL AND DERIVATIVES THEREOF, AND (C) AN ALIPHATIC PRIMARY AMINE. ALSO, A COMPOSITION FOR NUCLEIC ACID DELIVERY IS PREPARED BY MIXING THE CARRIER FOR NUCLEIC ACID DELIVERY WITH A NUCLEIC ACID.