| 发明名称 |
COMBINATIONS OF ANTIBODIES SELECTIVE FOR A TUMOR NECROSIS FACTOR-RELATED APOPTOSIS-INDUCING LIGAND RECEPTOR AND OTHER THERAPEUTIC AGENTS |
| 摘要 |
An antibody of the invention interacts with human DR5 or with human DR4 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Methods and uses for the antibodies, optionally in combination with various therapeutic agents, are detailed, including treatment of apoptosis-related disease and treatment of dysregulated cell growth. |
| 申请公布号 |
PL216750(B1) |
申请公布日期 |
2014.05.30 |
| 申请号 |
PL20020374061 |
申请日期 |
2002.10.25 |
| 申请人 |
UAB RESEARCH FOUNDATION |
发明人 |
ZHOU TONG;ICHIKAWA KIMIHISA;KIMBERLY ROBERT P.;KOOPMAN WILLIAM J.;OSHUMI JUN;LOBUGLIO ALBERT F.;BUCHSBAUM DONALD J. |
| 分类号 |
A61K39/395;C12N15/09;A61K31/337;A61K31/404;A61K31/519;A61K31/704;A61K35/12;A61K38/00;A61K41/00;A61K45/00;A61K45/06;A61P1/00;A61P3/10;A61P5/14;A61P7/02;A61P7/04;A61P7/06;A61P9/10;A61P11/06;A61P13/12;A61P15/00;A61P17/00;A61P17/06;A61P19/02;A61P21/04;A61P25/00;A61P29/00;A61P31/04;A61P31/12;A61P33/06;A61P35/00;A61P37/00;A61P37/02;A61P37/06;A61P37/08;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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