| 摘要 |
602872 Disclosed is crystalline (2S)-2-[{ (S)-2-(2-morpholinoacetamido)-1-oxo-propyl} amino]-3-(4-methoxyphenyl)-N-((S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-yl)propanamide having the structure of Formula (II) (and which is typically in the form of a toluene solvate), wherein the crystalline compound has 2θvalues 3.62±0.20; 6.52±0.20; 7.20±0.20; 8.66±0.20; 0.04±0.20; 10.82±0.20; 12.98±0.20; 14.42±0.20; 16.46±0.20; 17.32±0.20; 17.98±0.20; 18.02±0.20; 18.88±0.20; 19.06±0.20; 19.56±0.20; 19.88±0.20; 20.40±0.20; 21.36±0.20; 22.16±0.20; 23.20±0.20; 25.40±0.20; and 28.82±0.20. Said crystalline compound is obtainable by a method comprising: (i) preparing a solution of a compound of Formula (II) in an organic solvent such as toluene; (ii) bringing the solution to supersaturation to cause formation of crystals; and (iii) isolating the crystals. |
