发明名称 Spiropiperidine compounds as orl-1 receptor antagonists
摘要 600006 ORL-1 receptor antagonists of formula I, their uses, and methods for their preparation are described. ORL-1 antagonists are deemed to be useful; in the treatment of depression and/or the treatment of excess body fat, obesity, and/or weight maintenance post treatment for being overweight or obese, or in the treatment of migraine. Certain compounds have also demonstrated through animal models that the compounds of the present disclosure are useful for the treatment of migraine. Particularly the following compounds are disclosed: [2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4’-piperidine]-1’-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol; 2-chloro-4,4-difluoro-1’-[[3-methyl-1-[3-(pyrazol-1-ylmethyl)-2-pyridyl]pyrazol-4-yl]methyl]spiro[5H-thieno[2,3-c]pyran-7,4’-piperidine]; [4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c ]pyran-7,4’-piperidine]-1’-yl)methyl]-1-(3-fluoro-2-pyridyl)pyrazol-3-yl]methanol and [2-[4-[(2-Chloro-4,4-difluoro-spiro[5H -thieno[2,3-c ]pyran-7,4’-piperidine]-1’-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol.
申请公布号 NZ600006(A) 申请公布日期 2014.05.30
申请号 NZ20100600006 申请日期 2010.11.10
申请人 ELI LILLY AND COMPANY 发明人 BENITO COLLADO ANA BELEN;DIAZ BUEZO NURIA;JIMENEZ-AGUADO ALMA MARIA;LAFUENTE BLANCO CELIA;MARTINEZ-GRAU MARIA ANGELES;PEDREGAL-TERCERO CONCEPCION;TOLEDO ESCRIBANO MIGUEL ANGEL
分类号 C07D495/20;A61K31/444;A61P25/00 主分类号 C07D495/20
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