发明名称 |
SUBSTITUTED (E)-N'-(1-PHENYLETHYLIDENE) BENZOHYDRAZIDE ANALOGS AS HISTONE DEMETHYLASE INHIITORS |
摘要 |
<p>In one aspect, the invention relates to substituted (E)-N′-(1-phenylethylidene)benzohydrazide analogs, derivatives thereof, and related compounds, which are useful as inhibitors of lysine-specific histone demethylase, including LSD1; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions to treat disorders associated with dysfunction of the LSD1. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.</p> |
申请公布号 |
SG2014009609(A) |
申请公布日期 |
2014.05.29 |
申请号 |
SG20140009609 |
申请日期 |
2012.08.15 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION |
发明人 |
VANKAYALAPATI, HARIPRASAD;SORNA, VENKATASWAMY;WARNER, STEVE, L.;BEARSS, DAVID, J.;SHARMA, SUNIL;STEPHENS, BRET |
分类号 |
A01N37/36;C07C241/00;C07C243/00 |
主分类号 |
A01N37/36 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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