摘要 |
The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases. |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
CECCARELLI, SIMONA M.;CONTE, AURELIA;KUEHNE, HOLGER;KUHN, BERND;NEIDHART, WERNER;OBST SANDER, ULRIKE;RUDOLPH, MARKUS |