发明名称 |
Solid dispersions containing kinase inhibitors |
摘要 |
SOLID DISPERSIONS CONTAINING KINASE INHIBITORS A solid dispersion comprises, in essentially non-crystalline form, a kinase inhibitory compound, e.g., N-(4-{4-amino-7-[l-(2-hydroxyethyl)-1H-pyrazol-4-yl]thieno[3,2-c]pyridin 5 3-yllphenyl)-N'-(3-fluorophenyl)urea, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises dissolving the compound, the polymeric carrier and the surfactant in a suitable solvent, and removing the solvent to provide a solid matrix comprising the polymeric carrier and the surfactant and 0 having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a cancer. |
申请公布号 |
AU2014202435(A1) |
申请公布日期 |
2014.05.29 |
申请号 |
AU20140202435 |
申请日期 |
2014.05.05 |
申请人 |
ABBOTT LABORATORIES |
发明人 |
MILLER, JONATHAN;GOKHALE, RAJEEV;SCHMITT, ERIC A.;GAO, YI;LAFOUNTAINE, JUSTIN;DIAS, LLOYD |
分类号 |
A61K9/14;A61K9/16;A61K31/4743 |
主分类号 |
A61K9/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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