IGF-1R SPECIFIC ANTIBODIES USEFUL IN DETECTION AND DIAGNOSIS OF CELLULAR PROLIFERATIVE DISORDERS

摘要

PROBLEM TO BE SOLVED: To provide at least one reagent that can be used as a diagnostic or prognostic biomarker for detecting and/or monitoring oncogenic disorders especially those characterized by expression of IGF-1R or those that are mediated by aberrant IGF0-1R expression.SOLUTION: The present invention relates to mammalian antibodies designated 12B1 and antigen-binding portions thereof that specifically bind to insulin-like growth factor I receptor (IGF-IR), preferably human IGF-IR. Also included are chimeric antibodies, bispecific antibodies, derivatized antibodies, and single chain antibodies derived from said antibodies. Nucleic acid molecules encoding the mammalian antibodies and methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of IGF-1R.