| 摘要 |
Method and medical devices for generating and stabilizing micro or nano bubbles, and systems and methods for therapeutic applications using the bubbles, is provided. Two novel bubble generating means are provided: in-line capillary tubes and mix chambers flow focusing, and cross flow bubble generation with optimized bubble detachment means. A method and medical device to stabilize bubble sizes and improve bubble size homogeneity through rectified diffusion is disclosed. A method and system to facilitate acoustic activation of therapeutic agents using ultrasound energy is provided. Methods, systems, selected additives, and devices to permit therapeutic benefits such as ultrasound-guided precision drug delivery and real-time verification, acoustic activation of large tumour masses while avoiding acoustic shadowing, enhanced acoustic activation through longer retention of therapeutic agents at the point of interest, on demand means to combine inertial and non-inertial acoustic activation in a single treatment, enhancement of high intensity focused ultrasound treatments, light activation of photodynamic drugs at a depth within a patient using extracorporeal light sources, probes, or sonoluminescence, and initiation of time reversal acoustics focused ultrasound to permit highly localized treatment, are provided. |
