| 摘要 |
The present invention relates to a composition for enhancing sensitivity of an anti-cancer agent and, more particularly, to a composition comprising SMG-1 as an active ingredient for enhancing sensitivity of an anti-cancer agent; an anti-cancer composition including sorafenib and SMG-1 as active ingredients; and an anti-cancer composition comprising an expression vector including a polynucleotide encoding SMG-1 as an active ingredient. Suppressor of morphogenesis in genitalia-1 (SMG-1) according to the present invention has a function related to enhancing sensitivity of sorafenib on cancer cells. Therefore, when the resistance of sorafenib on cancer cell is controlled, SMG-1 helps suppression of growth of cancer cells and induction of apoptosis only using low concentration sorafenib, thereby enabling efficient cancer therapy. |
