摘要 |
A method including the steps a) providing a primary alcohol of the formula HO—(CH2)x—R1, where R1 is —OH, —SH, —NH2 or —COOR2; x is at least 3; and R2 is H, alkyl or aryl, b) oxidizing the primary alcohol by contacting it with an NAD(P)+-dependent alcohol dehydrogenase, and c) contacting the oxidation product of step a) with a transaminase, where the NAD(P)+-alcohol dehydrogenase and/or the transaminase is a recombinant or isolated enzyme. A whole cell catalyst for carrying out the method. The use of such a whole cell catalyst for oxidizing a primary alcohol. |
申请人 |
EVONIK DEGUSSA GMBH |
发明人 |
PÖTTER, MARKUS;HAAS, THOMAS;PFEFFER, JAN, CHRISTOPH;SKERRA, ARNE;KROUTIL, WOLFGANG;LERCHNER, ALEXANDRA;SATTLER, JOHANN, H.;SCHAFFER, STEFFEN;TAUBER, KATHARINA, CHRISTIN |