| 摘要 |
A method of resolution of an important chemical intermediate, 4,5-dimethoxy- 1-(methylaminomethyl)-benzocyclobutane, comprises the following steps: reacting its two enantiomers of 4,5-dimethoxy-1-(methylaminomethyl)-benzocyclobutane with di- p- toluoyl-L-tartaric acid (L-DTTA) or di- p -toluoyl-D-tartaric acid (D-DTTA) in a solution of alcohol or alcohol in water to give its salts, and then resolving the salts. This gives high enantiomer excess value, high yield which is more than 80% in total with normal separation and reversed separation. |
