Provided are engineered soluble hIL-17RA receptors with high affinity to hIL-17 that inhibit downstream IL17A induced signaling events in cells. Also provided are methods of inhibiting hIL-17A induced secretion of CXCL1 and/or IL-6 in cells, as well as methods of treating inflammation and/or inflammatory disorders in a subject.
申请公布号
EP2734541(A2)
申请公布日期
2014.05.28
申请号
EP20120814486
申请日期
2012.07.18
申请人
THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV, LTD.;AHARONI, AMIR
